3TY0

Structure of PPARgamma ligand binding domain in complex with (R)-5-(3-((3-(6-methoxybenzo[d]isoxazol-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)phenyl)-5-methyloxazolidine-2,4-dione

Summary for 3TY0

• Entry DOI: 10.2210/pdb3ty0/pdb
• Descriptor: Peroxisome proliferator-activated receptor gamma, (5R)-5-(3-{[3-(6-methoxy-1,2-benzoxazol-3-yl)-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl]methyl}phenyl)-5-methyl-1,3-oxazolidine-2,4-dione (3 entities in total)
• Functional Keywords: nuclear receptor ligand binding domain, transcription regulator
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P37231
• Total number of polymer chains: 2
• Total formula weight: 64156.22

Authors

Soisson, S.M.,Meinke, P.M.,McKeever, B.,Liu, W. (deposition date: 2011-09-23, release date: 2011-11-23, Last modification date: 2024-02-28)

• Primary citation: Liu, W.,Lau, F.,Liu, K.,Wood, H.B.,Zhou, G.,Chen, Y.,Li, Y.,Akiyama, T.E.,Castriota, G.,Einstein, M.,Wang, C.,McCann, M.E.,Doebber, T.W.,Wu, M.,Chang, C.H.,McNamara, L.,McKeever, B.,Mosley, R.T.,Berger, J.P.,Meinke, P.T.; Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor gamma (PPAR-gamma) modulators.; J.Med.Chem., 54:8541-8554, 2011; PubMed: 22070604; DOI: 10.1021/jm201061j

Experimental method

X-RAY DIFFRACTION (2 Å)