3TW8

GEF domain of DENND 1B in complex with Rab GTPase Rab35

Summary for 3TW8

Entry DOI	10.2210/pdb3tw8/pdb
Related	1YZN 2FOL
Descriptor	DENN domain-containing protein 1B, Ras-related protein Rab-35 (3 entities in total)
Functional Keywords	longin domain, rab gtpase, guanine exchange factor, protein transport
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): Q15286
Total number of polymer chains	4
Total formula weight	129806.04
Authors	Wu, X.D.,Kummel, D.,Reinisch, K.M. (deposition date: 2011-09-21, release date: 2011-11-16, Last modification date: 2024-02-28)
Primary citation	Wu, X.,Bradley, M.J.,Cai, Y.,Kummel, D.,De La Cruz, E.M.,Barr, F.A.,Reinisch, K.M. Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate. Proc.Natl.Acad.Sci.USA, 108:18672-18677, 2011 Cited by PubMed: 22065758 DOI: 10.1073/pnas.1110415108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation