3TVX
The structure of PDE4A with pentoxifylline at 2.84A resolution
Summary for 3TVX
Entry DOI | 10.2210/pdb3tvx/pdb |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Cytoplasm, perinuclear region. Isoform 2: Cytoplasm, perinuclear region. Isoform 4: Membrane; Peripheral membrane protein. Isoform 6: Cytoplasm, perinuclear region. Isoform 7: Cytoplasm: P27815 |
Total number of polymer chains | 2 |
Total formula weight | 78472.37 |
Authors | Badger, J.,Sridhar, V. (deposition date: 2011-09-20, release date: 2012-01-25, Last modification date: 2023-09-13) |
Primary citation | Recht, M.I.,Sridhar, V.,Badger, J.,Hernandez, L.,Chie-Leon, B.,Nienaber, V.,Torres, F.E. Fragment-Based Screening for Inhibitors of PDE4A Using Enthalpy Arrays and X-ray Crystallography. J Biomol Screen, 17:469-480, 2012 Cited by PubMed: 22223051DOI: 10.1177/1087057111430987 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.84 Å) |
Structure validation
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