3TVX
The structure of PDE4A with pentoxifylline at 2.84A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | polymer | 338 | 38772.1 | 2 | UniProt (P27815) Pfam (PF00233) In PDB | Homo sapiens (human) | DPDE2, PDE46 |
| 2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | A, B | 3,7-DIMETHYL-1-(5-OXOHEXYL)-3,7-DIHYDRO-1H-PURINE-2,6-DIONE | non-polymer | 278.3 | 2 | Chemie (PNX) | |||
| 5 | B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) |
Sequence modifications
A, B: 290 - 622 (UniProt: P27815)
| PDB | External Database | Details |
|---|---|---|
| Gly 285 | - | expression tag |
| Ala 286 | - | expression tag |
| Gly 287 | - | expression tag |
| Thr 288 | - | expression tag |
| Met 289 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 77544.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 928.2 | |
| All* | Total formula weight | 78472.4 |
