3TVX
The structure of PDE4A with pentoxifylline at 2.84A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 900 |
| Chain | Residue |
| A | HIS376 |
| A | HIS412 |
| A | ASP413 |
| A | ASP530 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 901 |
| Chain | Residue |
| A | HIS412 |
| A | ASP413 |
| A | THR483 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PNX A 902 |
| Chain | Residue |
| A | MET569 |
| A | GLN581 |
| A | PHE584 |
| A | TYR371 |
| A | ASN533 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 900 |
| Chain | Residue |
| B | HIS376 |
| B | HIS412 |
| B | ASP413 |
| B | ASP530 |
| B | MG901 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG B 901 |
| Chain | Residue |
| B | ASP413 |
| B | ZN900 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PNX B 902 |
| Chain | Residue |
| B | TYR371 |
| B | ASN533 |
| B | ILE548 |
| B | MET569 |
| B | GLN581 |
| B | PHE584 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 903 |
| Chain | Residue |
| B | ASP513 |
| B | ASN514 |
| B | TYR515 |
| B | ARG518 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 904 |
| Chain | Residue |
| B | ARG467 |
| B | ARG560 |
| B | LYS572 |
| B | HIS573 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF |
| Chain | Residue | Details |
| A | HIS412-PHE423 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"Q07343","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q07343","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17727341","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human PDE4a with 4-(3-butoxy-4-methoxyphenyl)methyl-2-imidazolidone.","authors":["Cheng R.K.Y.","Crawley L.","Barker J.","Wood M.","Felicetti B.","Whittaker M."]}},{"source":"PDB","id":"2QYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3I8V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"20196770","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
