3TV7

Human Rho-associated protein kinase 1 (ROCK 1) in COMPLEX WITH RKI1342

Summary for 3TV7

• Entry DOI: 10.2210/pdb3tv7/pdb
• Descriptor: Rho-associated protein kinase 1, 1-[(1R)-1-(3-methoxyphenyl)ethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: kinase, dimer, dimerization, myosin, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q13464
• Total number of polymer chains: 4
• Total formula weight: 191546.55

Authors

Martin, M.P.,Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2011-09-19, release date: 2012-02-15, Last modification date: 2023-09-13)

• Primary citation: Pireddu, R.,Forinash, K.D.,Sun, N.N.,Martin, M.P.,Sung, S.S.,Alexander, B.,Zhu, J.Y.,Guida, W.C.,Schonbrunn, E.,Sebti, S.M.,Lawrence, N.J.; Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2).; Medchemcomm, 3:699-709, 2012; PubMed: 23275831; DOI: 10.1039/C2MD00320A

Experimental method

X-RAY DIFFRACTION (2.75 Å)