3TUB
Crystal structure of SYK kinase domain with 1-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-3-((1R,2S)-2-phenylcyclopropyl)urea
Summary for 3TUB
Entry DOI | 10.2210/pdb3tub/pdb |
Related | 3TUC 3TUD |
Descriptor | Tyrosine-protein kinase SYK, 1-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-3-[(1R,2S)-2-phenylcyclopropyl]urea (3 entities in total) |
Functional Keywords | kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane (Probable): P43405 |
Total number of polymer chains | 1 |
Total formula weight | 34508.60 |
Authors | |
Primary citation | Lovering, F.,McDonald, J.,Whitlock, G.A.,Glossop, P.A.,Phillips, C.,Bent, A.,Sabnis, Y.,Ryan, M.,Fitz, L.,Lee, J.,Chang, J.S.,Han, S.,Kurumbail, R.,Thorarensen, A. Identification of Type-II Inhibitors Using Kinase Structures. Chem.Biol.Drug Des., 80:657-664, 2012 Cited by PubMed: 22759374DOI: 10.1111/j.1747-0285.2012.01443.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.23 Å) |
Structure validation
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