3TTZ

Crystal structure of a topoisomerase ATPase inhibitor

Summary for 3TTZ

• Entry DOI: 10.2210/pdb3ttz/pdb
• Related: 3U2D 3U2K
• Descriptor: DNA gyrase subunit B, 2-[(3S,4R)-4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-fluoropiperidin-1-yl]-1,3-thiazole-5-carboxylic acid, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: protein-inhibitor complex, atp-binding, structure-based drug design, antimicrobial, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
• Biological source: Staphylococcus aureus; More
• Cellular location: Cytoplasm : P0A0K8
• Total number of polymer chains: 2
• Total formula weight: 46054.51

Authors

Boriack-Sjodin, P.A.,Read, J.,Eakin, A.E.,Sherer, B.A. (deposition date: 2011-09-15, release date: 2011-11-16, Last modification date: 2024-02-28)

• Primary citation: Sherer, B.A.,Hull, K.,Green, O.,Basarab, G.,Hauck, S.,Hill, P.,Loch, J.T.,Mullen, G.,Bist, S.,Bryant, J.,Boriack-Sjodin, A.,Read, J.,Degrace, N.,Uria-Nickelsen, M.,Illingworth, R.N.,Eakin, A.E.; Pyrrolamide DNA gyrase inhibitors: Optimization of antibacterial activity and efficacy.; Bioorg.Med.Chem.Lett., 21:7416-7420, 2011; PubMed: 22041057; DOI: 10.1016/j.bmcl.2011.10.010

Experimental method

X-RAY DIFFRACTION (1.63 Å)