3TTP

Structure of multiresistant HIV-1 protease in complex with darunavir

Summary for 3TTP

Entry DOI	10.2210/pdb3ttp/pdb
Related	3ggt 3ggu 3qoz
Descriptor	HIV-1 protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	hydrolase, viral praticle, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus type 1 (HIV-1)
Total number of polymer chains	2
Total formula weight	22342.01
Authors	Saskova, K.G.,Brynda, J.,Kozisek, M.,Konvalinka, J.,Rezacova, P. (deposition date: 2011-09-15, release date: 2012-09-26, Last modification date: 2023-11-29)
Primary citation	Kozisek, M.,Lepsik, M.,Grantz Saskova, K.,Brynda, J.,Konvalinka, J.,Rezacova, P. Thermodynamic and structural analysis of HIV protease resistance to darunavir - analysis of heavily mutated patient-derived HIV-1 proteases. Febs J., 281:1834-1847, 2014 Cited by PubMed: 24785545 DOI: 10.1111/febs.12743 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.23 Å)

Structure validation