3TQ6

Crystal structure of human mitochondrial transcription factor A, TFAM or mtTFA, bound to the light strand promoter LSP

Summary for 3TQ6

• Entry DOI: 10.2210/pdb3tq6/pdb
• Descriptor: Transcription factor A, mitochondrial, DNA (5'-D(*TP*AP*AP*CP*AP*GP*TP*CP*AP*CP*CP*CP*CP*CP*CP*AP*AP*CP*(BRU)P*AP*AP*C)-3'), DNA (5'-D(*GP*TP*TP*AP*GP*TP*TP*GP*GP*GP*GP*GP*GP*TP*GP*AP*CP*TP*GP*TP*TP*A)-3'), ... (7 entities in total)
• Functional Keywords: transcription, transcription regulation, mitochondrion, dna-binding, hmgb-ubf_hmg-box, minor groove, tandem hmg boxes, transcription-dna complex, mitochondrial nucleoid, light-strand mitochondrial promoter, lsp, transcription/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Mitochondrion: Q00059
• Total number of polymer chains: 6
• Total formula weight: 78993.82

Authors

Rubio-Cosials, A.,Sydow, J.F.,Jimenez-Menendez, N.,Fernandez-Millan, P.,Montoya, J.,Jacobs, H.T.,Coll, M.,Bernado, P.,Sola, M. (deposition date: 2011-09-09, release date: 2011-11-02, Last modification date: 2024-02-28)

• Primary citation: Rubio-Cosials, A.,Sidow, J.F.,Jimenez-Menendez, N.,Fernandez-Millan, P.,Montoya, J.,Jacobs, H.T.,Coll, M.,Bernado, P.,Sola, M.; Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter.; Nat.Struct.Mol.Biol., 18:1281-1289, 2011; PubMed: 22037172; DOI: 10.1038/nsmb.2160

Experimental method

X-RAY DIFFRACTION (2.45 Å)