3TQ6

Crystal structure of human mitochondrial transcription factor A, TFAM or mtTFA, bound to the light strand promoter LSP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Transcription factor A, mitochondrial	polymer	214	25708.6	2	UniProt (Q00059) Pfam (PF00505) Pfam (PF09011)	Homo sapiens (human)	mtTFA, Mitochondrial transcription factor 1, MtTF1, Transcription factor 6, TCF-6, Transcription factor 6-like 2
2	C, E (C, E)	DNA (5'-D(*TP*AP*AP*CP*AP*GP*TP*CP*AP*CP*CP*CP*CP*CP*CP*AP*AP*CP*(BRU)P*AP*AP*C)-3')	polymer	22	6659.2	2		Homo sapiens
3	D, F (D, F)	DNA (5'-D(*GP*TP*TP*AP*GP*TP*TP*GP*GP*GP*GP*GP*GP*TP*GP*AP*CP*TP*GP*TP*TP*A)-3')	polymer	22	6909.4	2		Homo sapiens
4	G (B)	PENTAETHYLENE GLYCOL	non-polymer		238.3	1	Chemie (1PE)
5	H (C)	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
6	I (E)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
7	J, K, L, M, N... (A, B, C, D, E...)	water	water		18.0	186	Chemie (HOH)

Sequence modifications

A, B: 43 - 246 (UniProt: Q00059)

PDB	External Database	Details
Met 41	-	expression tag
Gly 42	-	expression tag
Leu 247	-	expression tag
Gln 248	-	expression tag
His 249	-	expression tag
His 250	-	expression tag
His 251	-	expression tag
His 252	-	expression tag
His 253	-	expression tag
His 254	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	78554.4
Non-Polymers*	Number of molecules	3
	Total formula weight	439.4
All*	Total formula weight	78993.8

*Water molecules are not included.