3TOC
Crystal structure of Streptococcus pyogenes Csn2
Summary for 3TOC
| Entry DOI | 10.2210/pdb3toc/pdb |
| Descriptor | Putative uncharacterized protein, CALCIUM ION, 1,2-ETHANEDIOL, ... (4 entities in total) |
| Functional Keywords | dna binding protein |
| Biological source | Streptococcus pyogenes |
| Total number of polymer chains | 2 |
| Total formula weight | 52715.45 |
| Authors | Bae, E.,Jung, D.K.,Koo, Y. (deposition date: 2011-09-05, release date: 2012-05-30, Last modification date: 2024-10-30) |
| Primary citation | Koo, Y.,Jung, D.K.,Bae, E. Crystal Structure of Streptococcus pyogenes Csn2 Reveals Calcium-Dependent Conformational Changes in Its Tertiary and Quaternary Structure Plos One, 7:e33401-e33401, 2012 Cited by PubMed Abstract: Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitute a microbial immune system against invading genetic elements, such as plasmids and phages. Csn2 is an Nmeni subtype-specific Cas protein, and was suggested to function in the adaptation process, during which parts of foreign nucleic acids are integrated into the host microbial genome to enable immunity against future invasion. Here, we report a 2.2 Å crystal structure of Streptococcus pyogenes Csn2. The structure revealed previously unseen calcium-dependent conformational changes in its tertiary and quaternary structure. This supports the proposed double-stranded DNA-binding function of S. pyogenes Csn2. PubMed: 22479393DOI: 10.1371/journal.pone.0033401 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.201 Å) |
Structure validation
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