3TKG
crystal structure of HIV model protease precursor/saquinavir complex
Summary for 3TKG
Entry DOI | 10.2210/pdb3tkg/pdb |
Related PRD ID | PRD_000454 |
Descriptor | Protease, CHLORIDE ION, GLYCEROL, ... (5 entities in total) |
Functional Keywords | hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus type 1 (HIV-1) |
Cellular location | Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367 |
Total number of polymer chains | 4 |
Total formula weight | 46520.40 |
Authors | Agniswamy, J.,Sayer, J.,Weber, I.,Louis, J. (deposition date: 2011-08-26, release date: 2012-04-25, Last modification date: 2023-09-13) |
Primary citation | Agniswamy, J.,Sayer, J.M.,Weber, I.T.,Louis, J.M. Terminal interface conformations modulate dimer stability prior to amino terminal autoprocessing of HIV-1 protease. Biochemistry, 51:1041-1050, 2012 Cited by PubMed: 22242794DOI: 10.1021/bi201809s PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.36 Å) |
Structure validation
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