3TJS
Crystal Structure of the complex between human cytochrome P450 3A4 and desthiazolylmethyloxycarbonyl ritonavir
Summary for 3TJS
Entry DOI | 10.2210/pdb3tjs/pdb |
Related | 3NXU |
Related PRD ID | PRD_001003 |
Descriptor | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, N-[(2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl]-N~2~-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide, ... (4 entities in total) |
Functional Keywords | monooxygenase, cytochrome p450, endoplasmic reticulum, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Single-pass membrane protein: P08684 |
Total number of polymer chains | 1 |
Total formula weight | 56954.10 |
Authors | Sevrioukova, I.F.,Poulos, T.L. (deposition date: 2011-08-24, release date: 2012-03-07, Last modification date: 2023-09-13) |
Primary citation | Sevrioukova, I.F.,Poulos, T.L. Interaction of human cytochrome P4503A4 with ritonavir analogs. Arch.Biochem.Biophys., 520:108-116, 2012 Cited by PubMed: 22410611DOI: 10.1016/j.abb.2012.02.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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