3TFN

Crystal structure of dehydrosqualene synthase (crtm) from s. aureus complexed with bph-1183

Summary for 3TFN

• Entry DOI: 10.2210/pdb3tfn/pdb
• Related: 3TFP 3TFV
• Descriptor: Dehydrosqualene synthase, (1-{2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethyl}cyclopentyl)acetic acid, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: head to head prenyl synthase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Staphylococcus aureus
• Total number of polymer chains: 1
• Total formula weight: 35232.35

Authors

Lin, F.-Y.,Liu, Y.-L.,Oldfield, E. (deposition date: 2011-08-16, release date: 2012-04-04, Last modification date: 2023-09-13)

• Primary citation: Lin, F.Y.,Zhang, Y.,Hensler, M.,Liu, Y.L.,Chow, O.A.,Zhu, W.,Wang, K.,Pang, R.,Thienphrapa, W.,Nizet, V.,Oldfield, E.; Dual dehydrosqualene/squalene synthase inhibitors: leads for innate immune system-based therapeutics.; Chemmedchem, 7:561-564, 2012; PubMed: 22290830; DOI: 10.1002/cmdc.201100589

Experimental method

X-RAY DIFFRACTION (2.07 Å)