3TFP
Crystal Structure of Dehydrosqualene Synthase (CrtM) from S. aureus Complexed with BPH-1162
Summary for 3TFP
Entry DOI | 10.2210/pdb3tfp/pdb |
Descriptor | Dehydrosqualene synthase, MAGNESIUM ION, 2-({2-chloro-6-[(2,4-dichlorophenyl)sulfanyl]benzyl}carbamoyl)benzoic acid, ... (4 entities in total) |
Functional Keywords | head-to-head prenyl synthase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 1 |
Total formula weight | 35302.87 |
Authors | Lin, F.-Y.,Liu, Y.-L.,Zhang, Y.,Oldfield, E. (deposition date: 2011-08-16, release date: 2012-04-04, Last modification date: 2023-09-13) |
Primary citation | Lin, F.Y.,Zhang, Y.,Hensler, M.,Liu, Y.L.,Chow, O.A.,Zhu, W.,Wang, K.,Pang, R.,Thienphrapa, W.,Nizet, V.,Oldfield, E. Dual dehydrosqualene/squalene synthase inhibitors: leads for innate immune system-based therapeutics. Chemmedchem, 7:561-564, 2012 Cited by PubMed: 22290830DOI: 10.1002/cmdc.201100589 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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