3T8S

Apo and InsP3-bound Crystal Structures of the Ligand-Binding Domain of an InsP3 Receptor

Summary for 3T8S

Entry DOI	10.2210/pdb3t8s/pdb
Descriptor	Inositol 1,4,5-trisphosphate receptor type 1, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE (2 entities in total)
Functional Keywords	beta-trefoil fold, armadillo repeat fold, ligand-binding domain, ligand(ip3)-binding, ip3, endoplasmic reticulum, ligand gated channel, ca2+ release channel, transport protein, membrane protein
Biological source	Rattus norvegicus (brown rat,rat,rats)
Total number of polymer chains	2
Total formula weight	132612.00
Authors	Lin, C.,Baek, K.,Lu, Z. (deposition date: 2011-08-01, release date: 2011-09-07, Last modification date: 2023-09-13)
Primary citation	Lin, C.C.,Baek, K.,Lu, Z. Apo and InsP(3)-bound crystal structures of the ligand-binding domain of an InsP(3) receptor. Nat.Struct.Mol.Biol., 18:1172-1174, 2011 Cited by PubMed Abstract: We report the crystal structures of the ligand-binding domain (LBD) of a rat inositol 1,4,5-trisphosphate receptor (InsP(3)R) in its apo and InsP(3)-bound conformations. Comparison of these two conformations reveals that LBD's first β-trefoil fold (β-TF1) and armadillo repeat fold (ARF) move together as a unit relative to its second β-trefoil fold (β-TF2). Whereas apo LBD may spontaneously transition between gating conformations, InsP(3) binding shifts this equilibrium toward the active state. PubMed: 21892169 DOI: 10.1038/nsmb.2112 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.77 Å)

Structure validation