3T8S
Apo and InsP3-bound Crystal Structures of the Ligand-Binding Domain of an InsP3 Receptor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005220 | molecular_function | inositol 1,4,5-trisphosphate-gated calcium channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0006816 | biological_process | calcium ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0070679 | molecular_function | inositol 1,4,5 trisphosphate binding |
| B | 0005220 | molecular_function | inositol 1,4,5-trisphosphate-gated calcium channel activity |
| B | 0005262 | molecular_function | calcium channel activity |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0006816 | biological_process | calcium ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0070679 | molecular_function | inositol 1,4,5 trisphosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE I3P B 603 |
| Chain | Residue |
| B | ARG265 |
| B | THR267 |
| B | ARG511 |
| B | TYR567 |
| B | ARG568 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21892169, ECO:0000269|PubMed:22286060, ECO:0000269|PubMed:36376291, ECO:0007744|PDB:3T8S, ECO:0007744|PDB:3UJ0, ECO:0007744|PDB:8EAR |
| Chain | Residue | Details |
| A | ARG265 | |
| A | GLN582 | |
| B | ARG265 | |
| B | GLN582 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21892169, ECO:0000269|PubMed:22286060, ECO:0007744|PDB:3T8S, ECO:0007744|PDB:3UJ0 |
| Chain | Residue | Details |
| A | THR267 | |
| A | PRO526 | |
| A | LYS583 | |
| B | THR267 | |
| B | PRO526 | |
| B | LYS583 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22286060, ECO:0007744|PDB:3UJ0 |
| Chain | Residue | Details |
| A | GLY268 | |
| A | ARG269 | |
| B | GLY268 | |
| B | ARG269 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P11881 |
| Chain | Residue | Details |
| A | LEU523 | |
| B | LEU523 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P11881 |
| Chain | Residue | Details |
| A | CYS56 | |
| B | CYS56 |
