3T6J

Structure of human DPPIII in complex with the opioid peptide Tynorphin, at 3.0 Angstroms

Summary for 3T6J

• Entry DOI: 10.2210/pdb3t6j/pdb
• Related: 3T6B
• Descriptor: Dipeptidyl peptidase 3, Tynorphin (3 entities in total)
• Functional Keywords: human dipeptidylpeptidase iii, entropy binding, opioid peptide complex, domain motion, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: Q9NY33
• Total number of polymer chains: 2
• Total formula weight: 82269.56

Authors

Bezerra, G.A.,Gruber, K. (deposition date: 2011-07-28, release date: 2012-04-04, Last modification date: 2023-11-01)

• Primary citation: Bezerra, G.A.,Dobrovetsky, E.,Viertlmayr, R.,Dong, A.,Binter, A.,Abramic, M.,Macheroux, P.,Dhe-Paganon, S.,Gruber, K.; Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III.; Proc.Natl.Acad.Sci.USA, 109:6525-6530, 2012; PubMed: 22493238; DOI: 10.1073/pnas.1118005109

Experimental method

X-RAY DIFFRACTION (2.976 Å)