3SX0
Crystal structure of Dot1l in complex with a brominated SAH analog
Summary for 3SX0
Entry DOI | 10.2210/pdb3sx0/pdb |
Descriptor | Histone-lysine N-methyltransferase, H3 lysine-79 specific, (2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(4-amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}sulfanyl)butanoic acid (non-preferred name), SULFATE ION, ... (5 entities in total) |
Functional Keywords | histone, methyltransferase, epigenetics, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : Q8TEK3 |
Total number of polymer chains | 1 |
Total formula weight | 48539.07 |
Authors | Yu, W.,Tempel, W.,Smil, D.,Schapira, M.,Li, Y.,Vedadi, M.,Nguyen, K.T.,Wernimont, A.K.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Brown, P.J.,Structural Genomics Consortium (SGC) (deposition date: 2011-07-14, release date: 2011-07-27, Last modification date: 2023-09-13) |
Primary citation | Yu, W.,Smil, D.,Li, F.,Tempel, W.,Fedorov, O.,Nguyen, K.T.,Bolshan, Y.,Al-Awar, R.,Knapp, S.,Arrowsmith, C.H.,Vedadi, M.,Brown, P.J.,Schapira, M. Bromo-deaza-SAH: a potent and selective DOT1L inhibitor. Bioorg. Med. Chem., 21:1787-1794, 2013 Cited by PubMed: 23433670DOI: 10.1016/j.bmc.2013.01.049 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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