3SX0
Crystal structure of Dot1l in complex with a brominated SAH analog
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone-lysine N-methyltransferase, H3 lysine-79 specific | polymer | 421 | 47980.7 | 1 | UniProt (Q8TEK3) Pfam (PF08123) | Homo sapiens (human) | DOT1-like protein, Histone H3-K79 methyltransferase, H3-K79-HMTase, Lysine N-methyltransferase 4 |
| 2 | B (A) | (2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(4-amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}sulfanyl)butanoic acid (non-preferred name) | non-polymer | 462.3 | 1 | Chemie (SX0) | |||
| 3 | C (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | D, E, F, G, H... (A) | UNKNOWN ATOM OR ION | non-polymer | 20 | Chemie (UNX) | ||||
| 5 | X (A) | water | water | 18.0 | 34 | Chemie (HOH) |
Sequence modifications
A: 1 - 420 (UniProt: Q8TEK3)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 47980.7 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 558.4 | |
| All* | Total formula weight | 48539.1 |
