3SU6

Crystal structure of NS3/4A protease variant A156T in complex with vaniprevir

Summary for 3SU6

• Entry DOI: 10.2210/pdb3su6/pdb
• Related: 3SU3 3SU4 3SU5 3SUD 3SUE 3SUF 3SUG 3SV6 3SV7 3SV8 3SV9
• Descriptor: NS3 protease, NS4A protein, (5R,7S,10S)-10-tert-butyl-N-{(1R,2R)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethylcyclopropyl}-15,15-dimethyl-3,9,12-trioxo-6,7,9,10,11,12,14,15,16,17,18,19-dodecahydro-1H,5H-2,23:5,8-dimethano-4,13,2,8,11-benzodioxatriazacyclohenicosine-7(3H)-carboxamide, GLYCEROL, ... (6 entities in total)
• Functional Keywords: drug resistance, drug design, protease inhibitors, serine protease, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Hepatitis C virus; More
• Total number of polymer chains: 1
• Total formula weight: 22624.92

Authors

Schiffer, C.A.,Romano, K.P. (deposition date: 2011-07-11, release date: 2012-09-05, Last modification date: 2024-02-28)

• Primary citation: Romano, K.P.,Ali, A.,Aydin, C.,Soumana, D.,Ozen, A.,Deveau, L.M.,Silver, C.,Cao, H.,Newton, A.,Petropoulos, C.J.,Huang, W.,Schiffer, C.A.; The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors.; Plos Pathog., 8:e1002832-e1002832, 2012; PubMed: 22910833; DOI: 10.1371/journal.ppat.1002832

Experimental method

X-RAY DIFFRACTION (1.1 Å)