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3SU6

Crystal structure of NS3/4A protease variant A156T in complex with vaniprevir

Functional Information from GO Data
ChainGOidnamespacecontents
A0006508biological_processproteolysis
A0008236molecular_functionserine-type peptidase activity
A0019087biological_processtransformation of host cell by virus
Functional Information from PDB Data
site_idAC1
Number of Residues23
DetailsBINDING SITE FOR RESIDUE SU3 A 1
ChainResidue
AHOH33
APHE1043
AHIS1057
AGLY1058
AASP1079
AASP1081
ALEU1135
ALYS1136
AGLY1137
ASER1138
AALA1139
AHOH56
APHE1154
AARG1155
ATHR1156
AALA1157
AHOH99
AHOH106
AHOH119
AHOH121
AHOH142
AHIS982
AGLN1041

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 2
ChainResidue
AHOH43
AHOH51
AHOH88
AHOH92
AARG1109
AHIS1110

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL A 3
ChainResidue
AHOH137
AHOH194
AASN1049
AGLY1050
AASP1121
ASER1122

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 4
ChainResidue
AHOH20
AHOH26
AHOH29
AHOH135
AHOH197
ATYR1006
AGLN1008
ATYR1056

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 5
ChainResidue
ACYS1097
ACYS1099
ACYS1145
AHIS1149

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PDB entries from 2024-11-06

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