3SU2
Crystal structure of NS3/4A protease variant A156T in complex with danoprevir
Summary for 3SU2
Entry DOI | 10.2210/pdb3su2/pdb |
Related | 3SSN 3SU1 3SU2 3SU3 3SU4 3SU5 3SU6 3SUD 3SUE 3SUF 3SUG 3SV6 3SV7 3SV8 3SV9 3SYT 3SZ0 3SZC 3SZF 3SZG 3SZW 3T0K |
Descriptor | Genome polyprotein, (2R,6S,12Z,13aS,14aR,16aS)-6-[(tert-butoxycarbonyl)amino]-14a-[(cyclopropylsulfonyl)carbamoyl]-5,16-dioxo-1,2,3,5,6,7,8 ,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoro-2H-isoindole-2-carboxylate, SULFATE ION, ... (5 entities in total) |
Functional Keywords | ns3, drug resistance, drug design, protease inhibitors, hcv, serine protease, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Hepatitis C virus subtype 1a More |
Total number of polymer chains | 1 |
Total formula weight | 22504.70 |
Authors | Schiffer, C.A.,Romano, K.P. (deposition date: 2011-07-11, release date: 2012-09-05, Last modification date: 2023-09-20) |
Primary citation | Romano, K.P.,Ali, A.,Aydin, C.,Soumana, D.,Ozen, A.,Deveau, L.M.,Silver, C.,Cao, H.,Newton, A.,Petropoulos, C.J.,Huang, W.,Schiffer, C.A. The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors. Plos Pathog., 8:e1002832-e1002832, 2012 Cited by PubMed: 22910833DOI: 10.1371/journal.ppat.1002832 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.496 Å) |
Structure validation
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