3SOM
crystal structure of human MMACHC
Summary for 3SOM
Entry DOI | 10.2210/pdb3som/pdb |
Descriptor | Methylmalonic aciduria and homocystinuria type C protein, COBALAMIN, CITRATE ANION, ... (7 entities in total) |
Functional Keywords | structural genomics, structural genomics consortium, sgc, cblc, organic aciduria, inborn errors of metabolism, cobalamin, vitamin b12, cobalt(iii), oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : Q9Y4U1 |
Total number of polymer chains | 16 |
Total formula weight | 549021.51 |
Authors | Krojer, T.,Froese, D.S.,von Delft, F.,Muniz, J.R.,Gileadi, C.,Vollmar, M.,Bountra, C.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Gravel, R.A.,Yue, W.W.,Oppermann, U.,Structural Genomics Consortium (SGC) (deposition date: 2011-06-30, release date: 2011-07-27, Last modification date: 2015-04-15) |
Primary citation | Froese, D.S.,Krojer, T.,Wu, X.,Shrestha, R.,Kiyani, W.,von Delft, F.,Gravel, R.A.,Oppermann, U.,Yue, W.W. Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function. Biochemistry, 51:5083-5090, 2012 Cited by PubMed: 22642810DOI: 10.1021/bi300150y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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