3SMR
Crystal structure of human WD repeat domain 5 with compound
Summary for 3SMR
Entry DOI | 10.2210/pdb3smr/pdb |
Descriptor | WD repeat-containing protein 5, 2-chloro-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | wdr5, sgc, structural genomics, structural genomics consortium, wd repeat domain 5, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : P61964 |
Total number of polymer chains | 4 |
Total formula weight | 140086.40 |
Authors | Dong, A.,Dombrovski, L.,Wasney, G.A.,Tempel, W.,Senisterra, G.,Bolshan, Y.,Smil, D.,Nguyen, K.T.,Hajian, T.,Poda, G.,Al-Awar, R.,Bountra, C.,Weigelt, J.,Edwards, A.M.,Brown, P.J.,Schapira, M.,Arrowsmith, C.H.,Vedadi, M.,Wu, H.,Structural Genomics Consortium (SGC) (deposition date: 2011-06-28, release date: 2011-08-31, Last modification date: 2023-09-13) |
Primary citation | Senisterra, G.,Wu, H.,Allali-Hassani, A.,Wasney, G.A.,Barsyte-Lovejoy, D.,Dombrovski, L.,Dong, A.,Nguyen, K.T.,Smil, D.,Bolshan, Y.,Hajian, T.,He, H.,Seitova, A.,Chau, I.,Li, F.,Poda, G.,Couture, J.F.,Brown, P.J.,Al-Awar, R.,Schapira, M.,Arrowsmith, C.H.,Vedadi, M. Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem. J., 449:151-159, 2013 Cited by PubMed: 22989411DOI: 10.1042/BJ20121280 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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