3SM0

tRNA-Guanine Transglycosylase in complex with lin-Benzohypoxanthine Inhibitor

Summary for 3SM0

Entry DOI	10.2210/pdb3sm0/pdb
Related	2Z7K 3EOS 3GEV 3GFN 3RR4 3S1G 3TLL 3V0Y
Descriptor	Queuine tRNA-ribosyltransferase, ZINC ION, 4-{2-[(cyclopentylmethyl)amino]ethyl}-2-(methylamino)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, ... (5 entities in total)
Functional Keywords	tim barrel, glycosyltransferase, metal-binding, queuosine, biosynthesis, transferase, trna processing, trna, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Zymomonas mobilis
Total number of polymer chains	1
Total formula weight	43515.72
Authors	Klebe, G.,Immekus, F.,Heine, A. (deposition date: 2011-06-27, release date: 2012-06-27, Last modification date: 2024-02-28)
Primary citation	Barandun, L.J.,Immekus, F.,Kohler, P.C.,Tonazzi, S.,Wagner, B.,Wendelspiess, S.,Ritschel, T.,Heine, A.,Kansy, M.,Klebe, G.,Diederich, F. From lin-Benzoguanines to lin-Benzohypoxanthines as Ligands for Zymomonas mobilis tRNA-Guanine Transglycosylase: Replacement of Protein-Ligand Hydrogen Bonding by Importing Water Clusters. Chemistry, 18:9246-9257, 2012 Cited by PubMed: 22736391 DOI: 10.1002/chem.201200809 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.57 Å)

Structure validation