3SM0

tRNA-Guanine Transglycosylase in complex with lin-Benzohypoxanthine Inhibitor

3SM0 の概要

• エントリーDOI: 10.2210/pdb3sm0/pdb
• 関連するPDBエントリー: 2Z7K 3EOS 3GEV 3GFN 3RR4 3S1G 3TLL 3V0Y
• 分子名称: Queuine tRNA-ribosyltransferase, ZINC ION, 4-{2-[(cyclopentylmethyl)amino]ethyl}-2-(methylamino)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, ... (5 entities in total)
• 機能のキーワード: tim barrel, glycosyltransferase, metal-binding, queuosine, biosynthesis, transferase, trna processing, trna, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Zymomonas mobilis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43515.72

構造登録者

Klebe, G.,Immekus, F.,Heine, A. (登録日: 2011-06-27, 公開日: 2012-06-27, 最終更新日: 2024-02-28)

• 主引用文献: Barandun, L.J.,Immekus, F.,Kohler, P.C.,Tonazzi, S.,Wagner, B.,Wendelspiess, S.,Ritschel, T.,Heine, A.,Kansy, M.,Klebe, G.,Diederich, F.; From lin-Benzoguanines to lin-Benzohypoxanthines as Ligands for Zymomonas mobilis tRNA-Guanine Transglycosylase: Replacement of Protein-Ligand Hydrogen Bonding by Importing Water Clusters.; Chemistry, 18:9246-9257, 2012; PubMed: 22736391; DOI: 10.1002/chem.201200809

実験手法

X-RAY DIFFRACTION (1.57 Å)