3SJT

Crystal structure of human arginase I in complex with the inhibitor Me-ABH, Resolution 1.60 A, twinned structure

3SJT の概要

• エントリーDOI: 10.2210/pdb3sjt/pdb
• 関連するPDBエントリー: 2AEB 3GMZ 3GN0 3SKK 3SL0 3SL1
• 分子名称: Arginase-1, MANGANESE (II) ION, [(5S)-5-amino-5-carboxyhexyl](trihydroxy)borate, ... (4 entities in total)
• 機能のキーワード: hydrolase, abh inhibitor derivative, twinning, 2-amino-6-borono-2-methylhexanoic acid, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P05089
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70191.56

構造登録者

Di Costanzo, L.,Christianson, D.W. (登録日: 2011-06-21, 公開日: 2011-07-20, 最終更新日: 2023-09-13)

• 主引用文献: Ilies, M.,Di Costanzo, L.,Dowling, D.P.,Thorn, K.J.,Christianson, D.W.; Binding of alpha , alpha-disubstituted amino acids to arginase suggests new avenues for inhibitor design.; J.Med.Chem., 54:5432-5443, 2011; PubMed: 21728378; DOI: 10.1021/jm200443b

実験手法

X-RAY DIFFRACTION (1.597 Å)