3SHV

Crystal structure of human MCPH1 tandem BRCT domains-gamma H2AX complex

Summary for 3SHV

• Entry DOI: 10.2210/pdb3shv/pdb
• Related: 3SHT
• Descriptor: Microcephalin, Histone H2A.x (3 entities in total)
• Functional Keywords: tandem brct domains h2ax, cell cycle
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q8NEM0; Nucleus : P16104
• Total number of polymer chains: 4
• Total formula weight: 48215.70

Authors

Shao, Z.H.,Li, F.D.,Yan, W. (deposition date: 2011-06-17, release date: 2011-12-28, Last modification date: 2023-11-01)

• Primary citation: Shao, Z.H.,Li, F.D.,Sy, S.M.-H.,Yan, W.,Zhang, Z.,Gong, D.,Wen, B.,Huen, M.S.Y.,Gong, Q.,Wu, J.,Shi, Y.; Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure; J.Struct.Biol., 177:459-468, 2012; PubMed: 22154951; DOI: 10.1016/j.jsb.2011.11.022

Experimental method

X-RAY DIFFRACTION (2.1 Å)