3SHV

Crystal structure of human MCPH1 tandem BRCT domains-gamma H2AX complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Microcephalin	polymer	206	22872.6	2	UniProt (Q8NEM0)	Homo sapiens (human)
2	C, D (C, D)	Histone H2A.x	polymer	10	1235.2	2	UniProt (P16104)	Homo sapiens
3	E, F, G, H (A, B, C, D)	water	water		18.0	182	Chemie (HOH)

Sequence modifications

A, B: 639 - 835 (UniProt: Q8NEM0)

PDB	External Database	Details
Met 630	-	expression tag
Gly 631	-	expression tag
His 632	-	expression tag
His 633	-	expression tag
His 634	-	expression tag
His 635	-	expression tag
His 636	-	expression tag
His 637	-	expression tag
Met 638	-	expression tag
Ala 761	Val 761	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	48215.7
All*	Total formula weight	48215.7

*Water molecules are not included.