3SHJ
Proteasome in complex with hydroxyurea derivative HU10
Summary for 3SHJ
Entry DOI | 10.2210/pdb3shj/pdb |
Related | 1RYP |
Descriptor | Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (17 entities in total) |
Functional Keywords | ubiquitin, drug development, cancer, immunology, protein degradation, unfolded protein substrates, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Saccharomyces cerevisiae (yeast) More |
Cellular location | Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 |
Total number of polymer chains | 28 |
Total formula weight | 705305.60 |
Authors | Gallastegui, N.,Beck, P.,Arciniega, M.,Hillebrand, S.,Huber, R.,Groll, M. (deposition date: 2011-06-16, release date: 2011-12-07, Last modification date: 2023-09-13) |
Primary citation | Gallastegui, N.,Beck, P.,Arciniega, M.,Huber, R.,Hillebrand, S.,Groll, M. Hydroxyureas as noncovalent proteasome inhibitors. Angew.Chem.Int.Ed.Engl., 51:247-249, 2012 Cited by PubMed: 22105886DOI: 10.1002/anie.201106010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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