3SH9
Crystal structure of fluorophore-labeled beta-lactamase PenP in complex with cefotaxime
Replaces: 3KGNSummary for 3SH9
Entry DOI | 10.2210/pdb3sh9/pdb |
Related | 3SH7 3SH8 |
Descriptor | Beta-lactamase, CEFOTAXIME, C3' cleaved, open, bound form, 1-[6-(dimethylamino)naphthalen-2-yl]ethanone, ... (4 entities in total) |
Functional Keywords | penp, beta-lactamase, cefotaxime, fluorophore, hydrolase-antibiotic complex, hydrolase/antibiotic |
Biological source | Bacillus licheniformis |
Total number of polymer chains | 2 |
Total formula weight | 60516.73 |
Authors | Wong, W.-T.,Zhao, Y.-X.,Leung, Y.-C. (deposition date: 2011-06-16, release date: 2011-07-27, Last modification date: 2023-11-01) |
Primary citation | Wong, W.-T.,Chan, K.-C.,So, P.-K.,Yap, H.-K.,Chung, W.-H.,Leung, Y.-C.,Wong, K.-Y.,Zhao, Y.-X. Increased structural flexibility at the active site of a fluorophore-conjugated beta-lactamase distinctively impacts its binding toward diverse cephalosporin antibiotics J.Biol.Chem., 286:31771-31780, 2011 Cited by PubMed: 21705325DOI: 10.1074/jbc.M110.198895 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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