3SGZ

High resolution crystal structure of rat long chain hydroxy acid oxidase in complex with the inhibitor 4-carboxy-5-[(4-chiorophenyl)sulfanyl]-1, 2, 3-thiadiazole.

Summary for 3SGZ

Entry DOI	10.2210/pdb3sgz/pdb
Related	1tb3
Descriptor	Hydroxyacid oxidase 2, FLAVIN MONONUCLEOTIDE, 5-[(4-methylphenyl)sulfanyl]-1,2,3-thiadiazole-4-carboxylic acid, ... (4 entities in total)
Functional Keywords	flavoprotein, homology, long chain hydroxy acid oxidase, inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Rattus norvegicus (rat)
Cellular location	Peroxisome: Q07523
Total number of polymer chains	3
Total formula weight	119302.93
Authors	Chen, Z.,Vignaud, C.,Jaafar, A.,Gueritte, F.,Guenard, D.,Lederer, F.,Mathews, F.S. (deposition date: 2011-06-15, release date: 2012-03-07, Last modification date: 2023-09-13)
Primary citation	Chen, Z.W.,Vignaud, C.,Jaafar, A.,Levy, B.,Gueritte, F.,Guenard, D.,Lederer, F.,Mathews, F.S. High resolution crystal structure of rat long chain hydroxy acid oxidase in complex with the inhibitor 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1, 2, 3-thiadiazole. Implications for inhibitor specificity and drug design. Biochimie, 94:1172-1179, 2012 Cited by PubMed: 22342614 DOI: 10.1016/j.biochi.2012.02.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation