3SGW

Crystal structure of ribose-5-phosphate isomerase B RpiB from Coccidioides immitis semi-covalently bound to malonic acid

3SGW の概要

• エントリーDOI: 10.2210/pdb3sgw/pdb
• 関連するPDBエントリー: 3QD5 3S5P 3SDW
• 分子名称: ribose 5-phosphate isomerase, MALONIC ACID, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: structural genomics, seattle structural genomics center for infectious disease, ssgcid, valley fever, coccidioidomycosis immitis, pathogenic fungus, rpib, dust-borne pathogen, iodoacetic acid, covalent inhibitor, ribulose-5-phosphate, ribose-5-phosphate, isomerase, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
• 由来する生物種: Coccidioides immitis (Valley fever fungus)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20008.60

構造登録者

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2011-06-15, 公開日: 2011-06-29, 最終更新日: 2023-09-13)

主引用文献

Edwards, T.E.,Abramov, A.B.,Smith, E.R.,Baydo, R.O.,Leonard, J.T.,Leibly, D.J.,Thompkins, K.B.,Clifton, M.C.,Gardberg, A.S.,Staker, B.L.,Van Voorhis, W.C.,Myler, P.J.,Stewart, L.J.
Structural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitis.
Bmc Struct.Biol., 11:39-39, 2011

PubMed Abstract: Ribose-5-phosphate isomerase is an enzyme that catalyzes the interconversion of ribose-5-phosphate and ribulose-5-phosphate. This family of enzymes naturally occurs in two distinct classes, RpiA and RpiB, which play an important role in the pentose phosphate pathway and nucleotide and co-factor biogenesis.

PubMed: 21995815
DOI: 10.1186/1472-6807-11-39

実験手法

X-RAY DIFFRACTION (1.7 Å)