3SEA
Structure of Rheb-Y35A mutant in GDP- and GMPPNP-bound forms
Summary for 3SEA
Entry DOI | 10.2210/pdb3sea/pdb |
Related | 1XTQ 1XTR 1XTS 2L0X 3OES |
Descriptor | GTP-binding protein Rheb, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total) |
Functional Keywords | globular, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): Q15382 |
Total number of polymer chains | 2 |
Total formula weight | 38587.86 |
Authors | Mazhab-Jafari, M.T.,Marshall, C.B.,Ishiyama, N.,Vuk, S.,Ikura, M. (deposition date: 2011-06-10, release date: 2012-06-20, Last modification date: 2023-09-13) |
Primary citation | Mazhab-Jafari, M.T.,Marshall, C.B.,Ishiyama, N.,Ho, J.,Di Palma, V.,Stambolic, V.,Ikura, M. An Autoinhibited Noncanonical Mechanism of GTP Hydrolysis by Rheb Maintains mTORC1 Homeostasis. Structure, 20:1528-1539, 2012 Cited by PubMed: 22819219DOI: 10.1016/j.str.2012.06.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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