3SA1

Bacuills anthracis Dihydrofolate Reductase bound propargyl-linked TMP analog, UCP1021

Summary for 3SA1

• Entry DOI: 10.2210/pdb3sa1/pdb
• Related: 3E0B 3JVX 3JWC 3JWF 3JWM 3S9U 3SA2 3SAI
• Descriptor: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-ethyl-5-{3-[2-methoxy-5-(pyridin-4-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine, ... (4 entities in total)
• Functional Keywords: oxidoreductase
• Biological source: Bacillus anthracis (anthrax,anthrax bacterium)
• Total number of polymer chains: 2
• Total formula weight: 41420.32

Authors

Anderson, A.C.,Beierlein, J.M. (deposition date: 2011-06-02, release date: 2012-06-13, Last modification date: 2023-09-13)

• Primary citation: Anderson, A.C.,Beierlein, J.M.,Viswanathan, K.,Wright, D.L.; SAR studies of heterocyclic propargyl-linked TMP analogs to Bacillus dihydrofolate reductase; to be published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)