3JVX

Crystal structure of Bacillus anthracis dihydrofolate reductase complexed with NADPH and 2,4-diamino-5-(3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120A)

Summary for 3JVX

• Entry DOI: 10.2210/pdb3jvx/pdb
• Related: 3EOB 3JV3 3JV5
• Descriptor: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-ethyl-5-[3-(3,4,5-trimethoxyphenyl)prop-1-yn-1-yl]pyrimidine-2,4-diamine, ... (4 entities in total)
• Functional Keywords: oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Bacillus anthracis
• Total number of polymer chains: 2
• Total formula weight: 42219.17

Authors

Anderson, A.C.,Beierlein, J.M.,Karri, N.G. (deposition date: 2009-09-17, release date: 2010-09-15, Last modification date: 2023-09-06)

• Primary citation: Beierlein, J.M.,Karri, N.G.,Anderson, A.C.; Mutational Studies into Trimethoprim Resistance in Bacillus anthracis Dihydrofolate Reductase; To be Published,

Experimental method

X-RAY DIFFRACTION (2.25 Å)