Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0050661 | molecular_function | NADP binding |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004146 | molecular_function | dihydrofolate reductase activity |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0046872 | molecular_function | metal ion binding |
B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 31 |
Details | BINDING SITE FOR RESIDUE NDP A 207 |
Chain | Residue |
A | VAL7 |
A | ARG45 |
A | LYS46 |
A | LYS46 |
A | ASN47 |
A | VAL63 |
A | THR64 |
A | ARG65 |
A | HIS78 |
A | PHE96 |
A | GLY97 |
A | ALA8 |
A | GLY98 |
A | ALA99 |
A | GLN100 |
A | ILE101 |
A | HOH163 |
A | HOH164 |
A | EKB208 |
A | HOH234 |
A | HOH256 |
A | HOH271 |
A | ILE15 |
A | HOH282 |
A | HOH285 |
A | GLY16 |
A | ASN19 |
A | ASN20 |
A | LEU21 |
A | TRP23 |
A | GLY44 |
site_id | AC2 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE EKB A 208 |
Chain | Residue |
A | MET6 |
A | VAL7 |
A | ALA8 |
A | ASN20 |
A | LEU21 |
A | TRP23 |
A | GLU28 |
A | VAL32 |
A | ASN47 |
A | ILE51 |
A | PHE96 |
A | TYR102 |
A | THR115 |
A | NDP207 |
site_id | AC3 |
Number of Residues | 34 |
Details | BINDING SITE FOR RESIDUE NDP B 207 |
Chain | Residue |
B | VAL7 |
B | ALA8 |
B | ILE15 |
B | GLY16 |
B | ASN19 |
B | ASN20 |
B | LEU21 |
B | TRP23 |
B | GLY44 |
B | ARG45 |
B | LYS46 |
B | LYS46 |
B | ASN47 |
B | VAL63 |
B | THR64 |
B | ARG65 |
B | HIS78 |
B | PHE96 |
B | GLY97 |
B | GLY98 |
B | ALA99 |
B | GLN100 |
B | ILE101 |
B | TYR102 |
B | LEU104 |
B | HOH166 |
B | HOH168 |
B | HOH191 |
B | HOH197 |
B | EKB208 |
B | HOH209 |
B | HOH220 |
B | HOH221 |
B | HOH237 |
site_id | AC4 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE EKB B 208 |
Chain | Residue |
B | MET6 |
B | VAL7 |
B | ALA8 |
B | ASN20 |
B | LEU21 |
B | GLU28 |
B | VAL32 |
B | ASN47 |
B | ILE51 |
B | PHE96 |
B | TYR102 |
B | THR115 |
B | NDP207 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGkdnnLPWrlps.ElqyVkktT |
Chain | Residue | Details |
A | VAL14-THR36 | |