3S9S

Ligand binding domain of PPARgamma complexed with a benzimidazole partial agonist

Summary for 3S9S

Entry DOI	10.2210/pdb3s9s/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, 1-(3,4-dichlorobenzyl)-2-methyl-N-[(1R)-1-phenylpropyl]-1H-benzimidazole-5-carboxamide, ... (4 entities in total)
Functional Keywords	ppar, nuclear receptor, transcription
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P37231 Nucleus (By similarity): Q15788
Total number of polymer chains	2
Total formula weight	34670.15
Authors	Lambert, M.H.,Xu, R.X. (deposition date: 2011-06-02, release date: 2012-06-06, Last modification date: 2023-09-13)
Primary citation	Sime, M.,Allan, A.C.,Chapman, P.,Fieldhouse, C.,Giblin, G.M.,Healy, M.P.,Lambert, M.H.,Leesnitzer, L.M.,Lewis, A.,Merrihew, R.V.,Rutter, R.A.,Sasse, R.,Shearer, B.G.,Wilson, T.M.,Xu, R.X.,Virley, D.J. Discovery of GSK1997132B a novel centrally penetrant benzimidazole PPARgamma partial agonist. Bioorg.Med.Chem.Lett., 21:5568-5572, 2011 Cited by PubMed: 21798739 DOI: 10.1016/j.bmcl.2011.06.088 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation