3S9S
Ligand binding domain of PPARgamma complexed with a benzimidazole partial agonist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Peroxisome proliferator-activated receptor gamma | polymer | 284 | 32583.9 | 1 | UniProt (P37231) Pfam (PF00104) | Homo sapiens (human) | PPAR-gamma, Nuclear receptor subfamily 1 group C member 3 |
| 2 | B (B) | Nuclear receptor coactivator 1 | polymer | 13 | 1633.9 | 1 | UniProt (Q15788) | Homo sapiens | |
| 3 | C (A) | 1-(3,4-dichlorobenzyl)-2-methyl-N-[(1R)-1-phenylpropyl]-1H-benzimidazole-5-carboxamide | non-polymer | 452.4 | 1 | Chemie (M0T) | |||
| 4 | D (A) | water | water | 18.0 | 52 | Chemie (HOH) |
Sequence modifications
A: 206 - 477 (UniProt: P37231)
| PDB | External Database | Details |
|---|---|---|
| Met 194 | - | expression tag |
| Lys 195 | - | expression tag |
| Lys 196 | - | expression tag |
| Gly 197 | - | expression tag |
| His 198 | - | expression tag |
| His 199 | - | expression tag |
| His 200 | - | expression tag |
| His 201 | - | expression tag |
| His 202 | - | expression tag |
| His 203 | - | expression tag |
| Gly 204 | - | expression tag |
| Arg 205 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 34217.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 452.4 | |
| All* | Total formula weight | 34670.2 |
