3S9S

Ligand binding domain of PPARgamma complexed with a benzimidazole partial agonist

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Peroxisome proliferator-activated receptor gamma	polymer	284	32583.9	1	UniProt (P37231) Pfam (PF00104) In PDB	Homo sapiens (human)	PPAR-gamma, Nuclear receptor subfamily 1 group C member 3
2	B	Nuclear receptor coactivator 1	polymer	13	1633.9	1	UniProt (Q15788) In PDB	Homo sapiens
3	A	1-(3,4-dichlorobenzyl)-2-methyl-N-[(1R)-1-phenylpropyl]-1H-benzimidazole-5-carboxamide	non-polymer		452.4	1	Chemie (M0T)
4		water	water		18.0	52	Chemie (HOH)

Sequence modifications

A: 206 - 477 (UniProt: P37231)

PDB	External Database	Details
Met 194	-	expression tag
Lys 195	-	expression tag
Lys 196	-	expression tag
Gly 197	-	expression tag
His 198	-	expression tag
His 199	-	expression tag
His 200	-	expression tag
His 201	-	expression tag
His 202	-	expression tag
His 203	-	expression tag
Gly 204	-	expression tag
Arg 205	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	34217.8
Non-Polymers*	Number of molecules	1
	Total formula weight	452.4
All*	Total formula weight	34670.2

*Water molecules are not included.