3S45

wild-type HIV-2 protease with antiviral drug amprenavir

Summary for 3S45

• Entry DOI: 10.2210/pdb3s45/pdb
• Related: 3EBZ 3EC0 3ECG 3NU3
• Descriptor: Protease, SODIUM ION, CHLORIDE ION, ... (7 entities in total)
• Functional Keywords: amprenavir, hiv/aids, drug resistance, aspartic protease, molecular recognition, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 2
• Total number of polymer chains: 2
• Total formula weight: 23141.29

Authors

Tie, Y.-F.,Wang, Y.-F.,Weber, I.T. (deposition date: 2011-05-18, release date: 2012-03-21, Last modification date: 2023-09-13)

• Primary citation: Tie, Y.,Wang, Y.F.,Boross, P.I.,Chiu, T.Y.,Ghosh, A.K.,Tozser, J.,Louis, J.M.,Harrison, R.W.,Weber, I.T.; Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors.; Protein Sci., 21:339-350, 2012; PubMed: 22238126; DOI: 10.1002/pro.2019

Experimental method

X-RAY DIFFRACTION (1.51 Å)