3S2K

Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.

3S2K の概要

• エントリーDOI: 10.2210/pdb3s2k/pdb
• 分子名称: Low-density lipoprotein receptor-related protein 6, Dickkopf-related protein 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: wnt co-receptor, beta-propeller, egf domain, wnt signaling, wnt inhibitor, glycosylation, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 157566.80

構造登録者

Ahn, V.E.,Chu, M.L.-H.,Choi, H.-J.,Tran, D.,Abo, A.,Weis, W.I. (登録日: 2011-05-16, 公開日: 2011-11-02, 最終更新日: 2020-07-29)

• 主引用文献: Ahn, V.E.,Chu, M.L.,Choi, H.J.,Tran, D.,Abo, A.,Weis, W.I.; Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6.; Dev.Cell, 21:862-873, 2011; PubMed: 22000856; DOI: 10.1016/j.devcel.2011.09.003

実験手法

X-RAY DIFFRACTION (2.8 Å)