3S04

Crystal structure of Escherichia coli type I signal peptidase in complex with an Arylomycin Lipoglycopeptide Antibiotic

3S04 の概要

• エントリーDOI: 10.2210/pdb3s04/pdb
• 関連するPDBエントリー: 1B12 1KN9 1T7D 3IIQ
• 関連するBIRD辞書のPRD_ID: PRD_000813
• 分子名称: Signal peptidase I, Glyco-Arylomycin, 14-methylhexadec-9-enoic acid, ... (5 entities in total)
• 機能のキーワード: mostly-beta fold, membrane bound, serine protease, secreted preproteins, cytoplasmic membrane, hydrolase-antibiotic complex, signal peptidase, leader peptidase, signal peptide, leader peptide, serine-lysine dyad, hydrolase/antibiotic
• 由来する生物種: Escherichia coli; 詳細
• 細胞内の位置: Cell inner membrane; Multi-pass membrane protein: P00803
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 58346.16

構造登録者

Paetzel, M.,Luo, C. (登録日: 2011-05-13, 公開日: 2011-10-05, 最終更新日: 2023-12-06)

• 主引用文献: Liu, J.,Luo, C.,Smith, P.A.,Chin, J.K.,Page, M.G.,Paetzel, M.,Romesberg, F.E.; Synthesis and characterization of the arylomycin lipoglycopeptide antibiotics and the crystallographic analysis of their complex with signal peptidase.; J.Am.Chem.Soc., 133:17869-17877, 2011; PubMed: 21999324; DOI: 10.1021/ja207318n

実験手法

X-RAY DIFFRACTION (2.44 Å)