3RZE

Structure of the human histamine H1 receptor in complex with doxepin

3RZE の概要

• エントリーDOI: 10.2210/pdb3rze/pdb
• 分子名称: Histamine H1 receptor, Lysozyme chimera, (3E)-3-(dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine, (3Z)-3-(dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine, ... (6 entities in total)
• 機能のキーワード: structural genomics, psi-biology, membrane protein, gpcr network, gpcr, hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane ; Multi-pass membrane protein : P35367
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53582.80

構造登録者

Shimamura, T.,Han, G.W.,Shiroishi, M.,Weyand, S.,Tsujimoto, H.,Winter, G.,Katritch, V.,Abagyan, R.,Cherezov, V.,Liu, W.,Kobayashi, T.,Stevens, R.,Iwata, S.,GPCR Network (GPCR) (登録日: 2011-05-11, 公開日: 2011-06-15, 最終更新日: 2023-09-13)

• 主引用文献: Shimamura, T.,Shiroishi, M.,Weyand, S.,Tsujimoto, H.,Winter, G.,Katritch, V.,Abagyan, R.,Cherezov, V.,Liu, W.,Han, G.W.,Kobayashi, T.,Stevens, R.C.,Iwata, S.; Structure of the human histamine H1 receptor complex with doxepin.; Nature, 475:65-70, 2011; PubMed: 21697825; DOI: 10.1038/nature10236

実験手法

X-RAY DIFFRACTION (3.1 Å)