3RYW

Crystal structure of P. vivax geranylgeranyl diphosphate synthase complexed with BPH-811

3RYW の概要

• エントリーDOI: 10.2210/pdb3ryw/pdb
• 関連するPDBエントリー: 3CC9 3RBM
• 分子名称: Farnesyl pyrophosphate synthase, {2-[5-(decyloxy)pyridin-3-yl]ethane-1,1-diyl}bis(phosphonic acid), MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: transferase, geranylgeranyl diphosphate synthase, bph-811
• 由来する生物種: Plasmodium vivax
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 187232.42

構造登録者

No, J.H.,Liu, Y.-L.,Zhang, Y.,Oldfield, E. (登録日: 2011-05-11, 公開日: 2012-05-23, 最終更新日: 2023-09-13)

• 主引用文献: No, J.H.,de Macedo Dossin, F.,Zhang, Y.,Liu, Y.L.,Zhu, W.,Feng, X.,Yoo, J.A.,Lee, E.,Wang, K.,Hui, R.,Freitas-Junior, L.H.,Oldfield, E.; Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity.; Proc.Natl.Acad.Sci.USA, 109:4058-4063, 2012; PubMed: 22392982; DOI: 10.1073/pnas.1118215109

実験手法

X-RAY DIFFRACTION (2.9 Å)