3RPS

Structure of human CK2alpha in complex with the ATP-competitive inhibitor 3-(4,5,6,7-tetrabromo-1H-benzotriazol-1-yl)propan-1-ol

Summary for 3RPS

Entry DOI	10.2210/pdb3rps/pdb
Related	1JWH 3OFM 3RP0
Descriptor	Casein kinase II subunit alpha, 3-(4,5,6,7-tetrabromo-1H-benzotriazol-1-yl)propan-1-ol, SULFATE ION, ... (5 entities in total)
Functional Keywords	eukaryotic protein kinase fold, atp ck2beta, phosphorylation, cytoplasm nucleus, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	80960.21
Authors	Bischoff, N.,Raaf, J.,Olsen, B.,Bretner, M.,Issinger, O.-G.,Niefind, K. (deposition date: 2011-04-27, release date: 2011-06-08, Last modification date: 2024-02-28)
Primary citation	Bischoff, N.,Raaf, J.,Olsen, B.,Bretner, M.,Issinger, O.G.,Niefind, K. Enzymatic activity with an incomplete catalytic spine - insights from a comparative structural analysis of human CK2alpha and its paralogous isoform CK2alpha' Mol.Cell.Biochem., 356:57-65, 2011 Cited by PubMed: 21739153 DOI: 10.1007/s11010-011-0948-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation