3RPS

Structure of human CK2alpha in complex with the ATP-competitive inhibitor 3-(4,5,6,7-tetrabromo-1H-benzotriazol-1-yl)propan-1-ol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 4B0 A 336

Chain	Residue
A	ARG47
A	LYS68
A	ASN117
A	ILE174

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 337

Chain	Residue
A	ARG21
A	LEU41

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 338

Chain	Residue
A	HOH348
A	HOH359
A	HIS148
A	THR314
A	ALA315

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 339

Chain	Residue
A	ARG155
A	ASN189

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 336

Chain	Residue
B	ARG21
B	GLN36
B	LEU41
B	ASP103
B	PRO104
B	HOH357

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 337

Chain	Residue
B	HIS148
B	ALA315

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 338

Chain	Residue
B	ARG155
B	ASN189

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnnek..........VVVK

Chain	Residue	Details
A	LEU45-LYS68

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI

Chain	Residue	Details
A	ILE152-ILE164

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	570
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Region: {"description":"Interaction with beta subunit","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---