3RIE

The structure of Plasmodium falciparum spermidine synthase in complex with 5'-methylthioadenosine and N-(3-aminopropyl)-trans-cyclohexane-1,4-diamine

Summary for 3RIE

Entry DOI	10.2210/pdb3rie/pdb
Descriptor	Spermidine synthase, 5'-DEOXY-5'-METHYLTHIOADENOSINE, trans-N-(3-aminopropyl)cyclohexane-1,4-diamine, ... (6 entities in total)
Functional Keywords	rossmann-like fold, rossmann fold, spermidine synthesis, aminopropyl transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Plasmodium falciparum
Total number of polymer chains	3
Total formula weight	98597.89
Authors	Williams, M.,Sprenger, J.,Persson, L.,Louw, A.I.,Birkholtz, L.,Al-Karadaghi, S. (deposition date: 2011-04-13, release date: 2012-04-25, Last modification date: 2023-09-13)
Primary citation	Burger, P.B.,Williams, M.,Sprenger, J.,Reeksting, S.B.,Botha, M.,Muller, I.B.,Joubert, F.,Birkholtz, L.M.,Louw, A.I. A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail. Malar J, 14:54-54, 2015 Cited by PubMed: 25651815 DOI: 10.1186/s12936-015-0572-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation