3RBG

Crystal structure analysis of Class-I MHC restricted T-cell associated molecule

Summary for 3RBG

• Entry DOI: 10.2210/pdb3rbg/pdb
• Descriptor: Cytotoxic and regulatory T-cell molecule, PHOSPHATE ION (3 entities in total)
• Functional Keywords: igv, crtam, structural genomics, psi-biology, new york structural genomics research consortium, nysgrc, atoms-to-animals: the immune function network, ifn, immune system
• Biological source: Homo sapiens (human)
• Cellular location: Membrane ; Single-pass type I membrane protein : O95727
• Total number of polymer chains: 4
• Total formula weight: 57364.71

Authors

Rubinstein, R.,Ramagopal, U.A.,Toro, R.,Nathenson, S.G.,Fiser, A.,Almo, S.C.,New York Structural Genomics Research Consortium (NYSGRC),Atoms-to-Animals: The Immune Function Network (IFN) (deposition date: 2011-03-29, release date: 2011-05-25, Last modification date: 2024-11-27)

Primary citation

Rubinstein, R.,Ramagopal, U.A.,Nathenson, S.G.,Almo, S.C.,Fiser, A.
Functional classification of immune regulatory proteins.
Structure, 21:766-776, 2013

PubMed Abstract: The members of the immunoglobulin superfamily (IgSF) control innate and adaptive immunity and are prime targets for the treatment of autoimmune diseases, infectious diseases, and malignancies. We describe a computational method, termed the Brotherhood algorithm, which utilizes intermediate sequence information to classify proteins into functionally related families. This approach identifies functional relationships within the IgSF and predicts additional receptor-ligand interactions. As a specific example, we examine the nectin/nectin-like family of cell adhesion and signaling proteins and propose receptor-ligand interactions within this family. Guided by the Brotherhood approach, we present the high-resolution structural characterization of a homophilic interaction involving the class-I MHC-restricted T-cell-associated molecule, which we now classify as a nectin-like family member. The Brotherhood algorithm is likely to have a significant impact on structural immunology by identifying those proteins and complexes for which structural characterization will be particularly informative.

PubMed: 23583034
DOI: 10.1016/j.str.2013.02.022

Experimental method

X-RAY DIFFRACTION (2.3 Å)